Dr. Q. Fang

Associate Professor and Canada Research Chair in Biophotonics
Department of Engineering Physics

McMaster University
1280 Main Street West, Hamilton
Ontario, Canada  L8S 4L7

office: ETB/403
email: qfang@mcmaster.ca
voice: (905) 525-9140 x 24227
fax: (905) 527-8409

B. S. (Nankai); M.S.; Ph.D. (East Carolina University), L.E.L.
Links: wiki.mcmaster.ca/Biophotonics

 

McMaster University has been awarded another Canada Research Chair bringing its total of the prestigious award to 58. The newest chair is held by Qiyin Fang and will focus on biophotonics - a fast growing interdisciplinary field that concentrates on applying physical, chemical and engineering advances to biological and medical challenges.

Fang joins McMaster as the Canada Research Chair in Biophotonics, Fang will work on photonics-based technologies for medical applications. His research will lead to real-time minimally-invasive techniques for the diagnosis and treatment of various diseases including vulnerable artery plaques and invasive brain cancers.

McMaster was awarded 70 Canada Research Chairs based on its research funding from the federal granting agencies - the Social Sciences and Humanities Research Council (SSHRC), the Natural Sciences and Engineering Research Council (NSERC) and the Canadian Institutes for Health Research (CIHR). The Chairs Program was launched in 2000 to help Canadian universities attract and retain the best researchers and achieve research excellence in natural sciences and engineering, health sciences, social sciences and humanities.

---

Member of:
McMaster School of Biomedical Engineering http://msbe.mcmaster.ca/

Brockhouse Institute for Materials Research (BIMR) http://www.brockhouse.mcmaster.ca/
Centre for Emerging Device Technologies (CEDT) http://www.eng.mcmaster.ca/cedt/

Courses teaching:
4I03/6I03 Introduction to Biophotonics
3G03 Optical Instrumentation

Research Interest:
Optical spectroscopy and imaging system for biomedical applications Research Web site: biophotonics.mcmaster.ca (under construction)

The focus of the McMaster Biophotonics Laboratory is on the research and technology development of optical spectroscopy and imaging systems for biomedical applications.

Summary of Research Activities

Clinically Compatible Optical Instrumentation and Analytical Methods

* Compact laser-induced lifetime fluorescence spectroscopy and imaging instrumentation systems
* Numerical methods for fast analysis of time-resolved fluorescence data
* Studies of fiberoptic probe designs for spectroscopic investigation of tissues
* Fluorescence lifetime imaging (FLIM) techniques at microscopic and macroscopic levels
* Optical MEMS based microsystems for implantable/ingestible minimally-invasive diagnosis

Applications of Laser Spectroscopy and Imaging to minimally-invasive in-vivo Tissues Diagnosis

* Oncology - Gastrointestinal (GI) diseases via endoscopic systems
* Oncology - neurosurgery (intraoperative diagnosis of brain tumors margins)
* real-time dosimetry for photodynamic therapy

Selected Publications:

2010

J. F. Lo, P. Butte, Q. Fang, S. J. Chen, T. Papaioannou, E. S. Kim, M. Gundersen, L. Marcu, “Multilayered MOEMS tunable spectrometer for fluorescence lifetime detection,” IEEE Photonics Technology Letters, 20(7):486-488, 2010.

2009

Y. Yuan, J-Y. Hwang, M. Krishnamoorthy, J. Ning, Y. Zhang, K. Ye, R. C. Wang, M. J. Deen, Q. Fang, “A high throughput AOTF-based time-resolved fluorescence spectrometer for optical biopsy,” Optics Letters, 34(7): 1132-1134, 2009

L. Marcu, J. A. Jo, Q. Fang, T. Papaioannou, T. Reil, J-H. Qiao, J. D. Baker, J. A. Freischlag, M. C. Fishbein, “Detection of Rupture-Prone Atherosclerotic Plaques by Time-Resolved Laser Induced Fluorescence Spectroscopy,” Atherosclerosis, Vol. 204(1): 156-164, 2009

Joe Lo, Shi-Jui Chen, Qiyin Fang, Thanassis Papaioannou, Eun-Sok Kim, Martin Gundersen and Laura Marcu, “Performance of Diaphragmed Microlens for a Packaged Microspectrometer,” Sensors, 9: 859-868, 2009

Munir ElDesouki, M. Jamal Deen, Qiyin Fang, Louis W. C. Liu, Frances Tse and David Armstrong, “CMOS Image Sensors for High Speed Applications,” Sensors, 9: 430-444, 2009

N. Faramarzpour, M. M. El-Desouki, M. J. Deen, S. Shirani, Q. Fang, “CMOS photodetector systems for low-level light applications,” Journal of Material Sciences: Materials in Electronics, invited, 20(S1): 87-93, 2009

2008

Y. Yuan, T. Papaioannou, Q. Fang, “Single shot acquisition of time-resolved fluorescence spectra using a multiple delay optical fiber bundle,” Optics Letters, 33(8): 791-793, 2008

N. Faramarzpour, M. J. Deen, S. Shirani and Q. Fang, “Fully Integrated Single Photon Avalanche Diode Detector in Standard CMOS 0.18μm Technology,” IEEE Transactions on Electron Devices, Vol. 55(3): 760-767, 2008

J. A. Russell, K. R. Diamond, T. Collins, H. F. Tiedje, J. E. Hayward, T. J. Farrell, M. S. Patterson, Q. Fang, “Characterization of Fluorescence Lifetime of Photofrin and Delta-Aminolevulinic Acid Induced Protoporphyrin IX in Living Cells using Single and Two-photon Excitation,” IEEE Journal of Selected Topics in Quantum Electronics, 14(1): 158-166, 2008

M. Kfouri, O. Marinov, P. Quevedo, N. Faramarzpour, S. Shirani, L. W-C. Liu, Q. Fang, M. J. Deen, “Towards a Miniaturized Wireless Fluorescence-Based Diagnostic Imaging System,” IEEE Journal of Se-lected Topics in Quantum Electronics, 14(1): 226-234, 2008

N. Faramarzpour, M. M. El-Desouki, M. J. Deen, Q. Fang, S. Shrani and L. W-C. Liu, “CMOS Imaging for Biomedical Applications,” IEEE Potentials, May/June: 31-36, 2008

2007

N. Faramarzpour, M. J. Deen, S. Shirani, Q. Fang, L. W. C. Liu, F. Campos, and J. W. Swart, “CMOS based active pixel for low-light-level detection: analysis and measurements,” IEEE Transactions on Elec-tron Devices, 54(12): 3229-3237, 2007

J. A. Jo, L. Marcu, Q. Fang, T. Papaioannou, J. H. Qiao, M. C. Fishbein, B. Beseth, A. H. Dorafshar, T. Reil, D. Baker, J. Freischlag, “New Methods for Time-resolved Fluorescence Spectroscopy Data Analysis Based on the Laguerre Expansion Technique Applications in Tissue Diagnosis,” Methods of Information in Medicine, Vol. 46(2): 206-211, 2007

J. F. Lo, Q. Fang, L. Marcu and E. S. Kim, “Wafer-level packaging of three-dimensional MOEMS device with lens diaphragm,” IEEE International Conference on Micro-Electrical-Mechanical Systems (MEMS), Jan. 21-25, 2007, Japan

2006

J. A. Jo, Q. Fang, T. Papaioannou, J. D. Baker, A. H. Dorafshar, T. Reil, J. H. Qiao, M. C. Fishbein, J. A. Freischlag, L. Marcu; “Laguerre-based method for analysis of time-resolved fluorescence data: application to in-vivo characterization and diagnosis of atherosclerotic lesions,” Journal of Biomedical Optics, Vol. 11 (2): 021004, 2006

W. H. Yong, P. V. Butte, B. K. Pikul, J. A. Jo, Q. Fang, T. Papaioannou, K. L. Black, and L. Marcu, “Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy,” Frontiers in Biosciences, Vol. 11: 1255-1263, 2006

2005

J. A. Jo, Q. Fang, L. Marcu, “Ultrafast method for the analysis of fluorescence lifetime imaging microscopy data based on the Laguerre expansion technique,” IEEE Journal of Selected Topics in Quantum Electronics, Vol. 11(4): 835-845, 2005

2004

L. Marcu, Q. Fang, J. A. Jo, T. Papaioannou, A. Dorafshar, T. Reil, J.H. Qiao, D. Baker, J. A. Freischlag M. C. Fishbein,. In-Vivo Detection of Macrophages in a Rabbit Atherosclerotic Model by Time-Resolved Laser-Induced Fluorescence Spectroscopy. Atherosclerosis, Vol. 181(2): 295-303, 2005

Q. Fang, T. Papaioannou, J. Jo, R. Vaitha, K. Shastry, and L. Marcu, “Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics,” Review of Scientific Instrument, Vol. 75(1): 151-162, 2004

Q. Fang and X. H. Hu, “Modeling of skin-tissue ablation by nanoseconds laser pulses from ultra violet to near-inferred and comparison with experimental results,” IEEE Journal of Quantum Electronics, Vol.40(1): 69-77, 2004

J. A. Jo, Q. Fang, T. Papaioannou, and L. Marcu, “Fast model-free deconfolution of fluorescence decay for analysis of biological systems,” Journal of Biomedical Optics, Vol. 9(4):743-752, 2004

T. Papaioannou, N. Preyer, Q. Fang, M. Carnohan, R. Ross, A. Brightwell, G. Cottone, L. Jones, and L. Marcu, “Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm,” Applied Optics, Vol. 43(14): 2846-2860, 2004.

 

For more information on Dr. Qiyin Fang please visit http://wiki.mcmaster.ca/Biophotonics/people:fangq